(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

Base Information

Chemical Name:(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid
CAS No.:1309685-95-7
Molecular Formula:C₂HF₃O₂*C₂₃H₂₃Cl₂FN₂O₃
Molecular Weight:579.376
Hs Code.:

Synonyms:(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

There total 9 articles about (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1309685-92-4
rac-(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1309685-95-7
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

Guidance literature:: In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1219086-34-6
2-[(E)-(3,3-dimethylbutylidene)amino]acetic acid tert-butyl ester

: 1309685-95-7
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; silver fluoride / dichloromethane / 18 h / 20 °C

1.2: 2 h / 120 °C

2.1: Resolution of racemate

3.1: dichloromethane / 18 h / 20 °C

With silver fluoride; triethylamine; In dichloromethane;

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1309685-95-7
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 3 h / 50 °C

2.1: triethylamine; silver fluoride / dichloromethane / 18 h / 20 °C

2.2: 2 h / 120 °C

3.1: Resolution of racemate

4.1: dichloromethane / 18 h / 20 °C

With piperidine; silver fluoride; triethylamine; In methanol; dichloromethane;