acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

Base Information

Chemical Name:acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester
CAS No.:1309686-64-3
Molecular Formula:C₃₄H₃₆Cl₂FN₃O₆
Molecular Weight:672.581
Hs Code.:

acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

Synonyms:acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

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Chemical Property of acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

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Technology Process of acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

There total 13 articles about acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2-(4-amino-2-methoxyphenoxy)ethyl acetate

: 1309685-95-7
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid

: 1309686-64-3
acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

Guidance literature:: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid; With N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride; In dichloromethane; at 20 ℃; for 0.133333h;

2-(4-amino-2-methoxyphenoxy)ethyl acetate; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 1309686-63-2
2-(2-methoxy-4-nitrophenoxy)ethyl acetate

: 1309686-64-3
acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

2.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

2.2: 20 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;

Reference yield:

: 3251-56-7
2-methoxy-4-nitrophenol

: 1309686-64-3
acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 70 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

3.1: pyridine / tetrahydrofuran / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

5.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

5.2: 20 h / 20 °C

With pyridine; hydrogenchloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;