(1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

Base Information

Chemical Name:(1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester
CAS No.:183498-48-8
Molecular Formula:C₃₃H₃₄N₂O₆
Molecular Weight:554.643
Hs Code.:

Synonyms:(1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

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Chemical Property of (1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

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Technology Process of (1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

There total 6 articles about (1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 93-97-0
benzoic acid anhydride

: 183498-42-2
(1S,2S,3R,4S)-1-(4-benzyloxy-3-benzyloxymethyl-2-hydroxymethyl-cyclopentyl)-thymine

: 183498-48-8
(1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; for 4h; Heating;
DOI:10.1016/0040-4020(96)00755-7

Reference yield:

: 132151-65-6
(E)-3-methoxy-2-methylacryloyl isocyanate

: 183498-48-8
(1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CH₂Cl₂ / 0.5 h / -60 - 20 °C

2: 85 percent / 2 N aq. HCl / ethanol / 20 h / Heating

3: 91 percent / pyridine, DMAP / CH₂Cl₂ / 4 h / Heating

With pyridine; hydrogenchloride; dmap; In ethanol; dichloromethane;
DOI:10.1016/0040-4020(96)00755-7

Reference yield:

: 183498-38-6
(1S,2S,3R,4S)-4-benzyloxy-3-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylamine

: 183498-48-8
(1S,2R,3S,5S)-benzoic acid 3-benzyloxy-2-benzyloxymethyl-5-(thymin-1-yl)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CH₂Cl₂ / 0.5 h / -60 - 20 °C

2: 85 percent / 2 N aq. HCl / ethanol / 20 h / Heating

3: 91 percent / pyridine, DMAP / CH₂Cl₂ / 4 h / Heating

With pyridine; hydrogenchloride; dmap; In ethanol; dichloromethane;
DOI:10.1016/0040-4020(96)00755-7