{(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Base Information

Chemical Name:{(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate
CAS No.:1012860-24-0
Molecular Formula:C₂₉H₂₄ClF₃N₄O₄
Molecular Weight:584.982
Hs Code.:

Synonyms:{(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

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Chemical Property of {(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

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Technology Process of {(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

There total 5 articles about {(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 896746-86-4
(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

: 1012860-24-0
{(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; lithium hydroxide / 6 h / 0 - 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 12 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

4: 12 h / 20 °C

With methanol; tetrabutyl ammonium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.molstruc.2014.07.046

Reference yield:

: 896746-84-2
(R)-3-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 1012860-24-0
{(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C

2.1: sodium hydride / 1 h / 0 °C

2.2: 12 h / 20 °C

3.1: methanol; lithium hydroxide / 6 h / 0 - 20 °C

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 12 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

6.1: 12 h / 20 °C

With 1H-imidazole; methanol; tetrabutyl ammonium fluoride; sodium hydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.molstruc.2014.07.046

Reference yield:

: 896746-85-3
(R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 1012860-24-0
{(3R)-1-[2-(allylamino)-2-oxoethyl]2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1 h / 0 °C

1.2: 12 h / 20 °C

2.1: methanol; lithium hydroxide / 6 h / 0 - 20 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 12 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

5.1: 12 h / 20 °C

With methanol; tetrabutyl ammonium fluoride; sodium hydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.molstruc.2014.07.046