(3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Base Information

Chemical Name:(3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one
CAS No.:1380402-62-9
Molecular Formula:C₃₄H₂₇NO₃S
Molecular Weight:529.659
Hs Code.:

Synonyms:(3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Chemical Property of (3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Technology Process of (3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

There total 8 articles about (3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 358621-92-8
N-(p-tolylsulfonyl)-1,3-diphenyl-2-propen-1-imine

: 581-96-4
2-naphthylacetic acid

: 1380402-62-9
(3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; stereoselective reaction;
DOI:10.1021/acscatal.5b02121

Reference yield:

: 201230-82-2
carbon monoxide

: C₂₂H₂₁NO₂S

: 939-26-4
2-bromomethylnaphthyl bromide

: 1380402-62-9
(3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With (+)-(R,S)-Fused-BTM; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 30 ℃; for 12h; under 750.075 Torr; Overall yield = > 99 %; Overall yield = 53.4 mg; stereoselective reaction;
DOI:10.1002/anie.201901501

Reference yield:

: 37859-25-9
2-naphthylacetyl chloride

: 1380402-62-9
(3R,4R)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 1372996-84-3
(3S,4S)-3-(naphthalen-2-yl)-4,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: (R)-5-benzyl-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; tetramethlyammonium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With (R)-5-benzyl-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; tetramethlyammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ol300676w