N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Base Information

Chemical Name:N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine
CAS No.:370879-47-3
Molecular Formula:C₂₅H₃₃FN₈OSi
Molecular Weight:508.674
Hs Code.:

<i>N</i>'-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Synonyms:N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Suppliers and Price of N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

There total 9 articles about N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 102191-92-4
tert-butyldimethylsiloxyacetaldehyde

: 428854-24-4
2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6- triamine

: 370879-47-3
N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Guidance literature:: With 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 5h;
DOI:10.1016/S0968-0896(02)00034-2

Reference yield:

: 51859-98-4
(2-fluorobenzyl)hydrazine

: 370879-47-3
N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: TFA / dioxane / 8 h / Heating

2.1: TFA / dioxane / 72 h / Heating

3.1: 100 percent / NH₃ / methanol / 48 h / 20 °C

4.1: 100 percent / TFAA / pyridine / 8 h

5.1: 100 percent / methanol / 2 h / 20 °C

6.1: NH₄Cl; HOAc / methanol / 8 h / Heating

6.2: 76 percent / Na₂CO₃ / H₂O / 20 °C

7.1: 73 percent / NaOMe / dimethylformamide / 12 h / 110 °C

8.1: 59 percent / H₂ / Raney-Ni / dimethylformamide / 22 h / 62 °C / 48753.9 Torr

9.1: 38 percent / molecular sieves 3 Angstroem; NaCNBH₃; AcOH / methanol / 5 h / 20 °C

With 3 A molecular sieve; ammonia; hydrogen; sodium methylate; sodium cyanoborohydride; ammonium chloride; acetic acid; trifluoroacetic acid; trifluoroacetic anhydride; nickel; In 1,4-dioxane; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00034-2

Reference yield:

: 256376-65-5
1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

: 370879-47-3
N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / methanol / 2 h / 20 °C

2.1: NH₄Cl; HOAc / methanol / 8 h / Heating

2.2: 76 percent / Na₂CO₃ / H₂O / 20 °C

3.1: 73 percent / NaOMe / dimethylformamide / 12 h / 110 °C

4.1: 59 percent / H₂ / Raney-Ni / dimethylformamide / 22 h / 62 °C / 48753.9 Torr

5.1: 38 percent / molecular sieves 3 Angstroem; NaCNBH₃; AcOH / methanol / 5 h / 20 °C

With 3 A molecular sieve; hydrogen; sodium methylate; sodium cyanoborohydride; ammonium chloride; acetic acid; nickel; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00034-2