2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

Base Information

Chemical Name:2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide
CAS No.:1586026-61-0
Molecular Formula:C₃₃H₃₁N₃O₂
Molecular Weight:501.628
Hs Code.:

Synonyms:2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

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Chemical Property of 2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

Chemical Property:

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Technology Process of 2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

There total 4 articles about 2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1429896-37-6
2-benzyl-3-(4-methoxyphenyl)-2-methyl-N-(quinolin-8-yl)propanamide

: 540-37-4
p-aminoiodobenzene

: 1586026-61-0
2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

Guidance literature:: With nickel(II) triflate; sodium carbonate; dimethyl sulfoxide; triphenylphosphine; Trimethylacetic acid; In 1,4-dioxane; at 160 ℃; for 36h; Schlenk technique; Sealed tube; Inert atmosphere;
DOI:10.1039/c4cc00716f

Reference yield: 46.0%

: 1429896-37-6
2-benzyl-3-(4-methoxyphenyl)-2-methyl-N-(quinolin-8-yl)propanamide

: 106-40-1
4-bromo-aniline

: 1586026-61-0
2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

Guidance literature:: With nickel(II) triflate; sodium carbonate; dimethyl sulfoxide; triphenylphosphine; Trimethylacetic acid; In 1,4-dioxane; at 160 ℃; for 36h; Schlenk technique; Sealed tube; Inert atmosphere;
DOI:10.1039/c4cc00716f

Reference yield:

: 696-62-8
para-iodoanisole

: 1586026-61-0
2-(4-aminobenzyl)-2-benzyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: nickel(II) triflate; triphenylphosphine; dimethyl sulfoxide; sodium carbonate; ortho-nitrobenzoic acid / 1,4-dioxane / 36 h / 160 °C / Schlenk technique; Sealed tube; Inert atmosphere

2: nickel(II) triflate; triphenylphosphine; dimethyl sulfoxide; Trimethylacetic acid; sodium carbonate / 1,4-dioxane / 36 h / 160 °C / Schlenk technique; Sealed tube; Inert atmosphere

With nickel(II) triflate; ortho-nitrobenzoic acid; sodium carbonate; dimethyl sulfoxide; triphenylphosphine; Trimethylacetic acid; In 1,4-dioxane;
DOI:10.1039/c4cc00716f