3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Base Information

Chemical Name:3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile
CAS No.:1231208-58-4
Molecular Formula:C₂₁H₁₄ClFN₂O₂S
Molecular Weight:412.872
Hs Code.:

Synonyms:3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Suppliers and Price of 3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

There total 5 articles about 3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 504-78-9
1,3-thiazolidine

: 1231209-07-6
4-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid

: 1231208-58-4
3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 54113-42-7
2,3-dibromo-5-(ethoxycarbonyl)furan

: 1231208-58-4
3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; XPhos; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki Coupling / 2: Suzuki Coupling;

Reference yield:

: 2434-03-9
4,5-dibromo-2-furoic acid

: 1231208-58-4
3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / ethanol / Reflux

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

3: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; XPhos; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; 2: Suzuki Coupling / 3: Suzuki Coupling;