2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI)

Base Information

Chemical Name:2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI)
CAS No.:299185-45-8
Molecular Formula:C₇H₁₅NO₂
Molecular Weight:145.202
Hs Code.:
Mol file:299185-45-8.mol

Synonyms:2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI)

Suppliers and Price of 2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI)

Chemical Property:

PSA：55.48000
LogP:0.57540

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI)

There total 12 articles about 2H-Pyran-2-ethanol,3-aminotetrahydro-,(2S,3S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 299185-45-8
2-((2S,3S)-3-Amino-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 12 steps

1.1: SOCl₂

2.1: Me₃SiCl

2.2: Et₃N

2.3: MeOH

3.1: LiAlH₄

4.1: DCC

5.1: DIBAH

7.1: tetrabutylammonium fluoride

7.2: NaOH / H₂O

7.3: N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole

8.1: trifluoroacetic acid / CH₂Cl₂

9.1: HCl

10.1: Et₃N

11.1: LiAlH₄

12.1: TsOH*H₂O / propan-2-ol / Heating

With hydrogenchloride; lithium aluminium tetrahydride; chloro-trimethyl-silane; thionyl chloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; isopropyl alcohol; 1.1: Esterification / 2.1: O-silylation / 2.2: Alkylation / 2.3: desilylation / 3.1: Reduction / 4.1: Cyclization / 5.1: Reduction / 6.1: Wittig reaction / 7.1: Cyclization / 7.2: Hydrolysis / 7.3: Cyclization / 8.1: Substitution / 9.1: Esterification / 10.1: Alkylation / 11.1: Reduction / 12.1: Substitution;
DOI:10.1016/S0040-4039(00)01004-2

Reference yield:

: 1499-55-4
L-glutamic acid 5-methyl ester

: 299185-45-8
2-((2S,3S)-3-Amino-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: Me₃SiCl

1.2: Et₃N

1.3: MeOH

2.1: LiAlH₄

3.1: DCC

4.1: DIBAH

6.1: tetrabutylammonium fluoride

6.2: NaOH / H₂O

6.3: N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole

7.1: trifluoroacetic acid / CH₂Cl₂

8.1: HCl

9.1: Et₃N

10.1: LiAlH₄

11.1: TsOH*H₂O / propan-2-ol / Heating

With hydrogenchloride; lithium aluminium tetrahydride; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; isopropyl alcohol; 1.1: O-silylation / 1.2: Alkylation / 1.3: desilylation / 2.1: Reduction / 3.1: Cyclization / 4.1: Reduction / 5.1: Wittig reaction / 6.1: Cyclization / 6.2: Hydrolysis / 6.3: Cyclization / 7.1: Substitution / 8.1: Esterification / 9.1: Alkylation / 10.1: Reduction / 11.1: Substitution;
DOI:10.1016/S0040-4039(00)01004-2

Reference yield:

: 55878-80-3
N-trityl-L-glutamic acid 5-methyl ester

: 299185-45-8
2-((2S,3S)-3-Amino-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: LiAlH₄

2.1: DCC

3.1: DIBAH

5.1: tetrabutylammonium fluoride

5.2: NaOH / H₂O

5.3: N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole

6.1: trifluoroacetic acid / CH₂Cl₂

7.1: HCl

8.1: Et₃N

9.1: LiAlH₄

10.1: TsOH*H₂O / propan-2-ol / Heating

With hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; isopropyl alcohol; 1.1: Reduction / 2.1: Cyclization / 3.1: Reduction / 4.1: Wittig reaction / 5.1: Cyclization / 5.2: Hydrolysis / 5.3: Cyclization / 6.1: Substitution / 7.1: Esterification / 8.1: Alkylation / 9.1: Reduction / 10.1: Substitution;
DOI:10.1016/S0040-4039(00)01004-2