(1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine

Base Information

Chemical Name:(1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine
CAS No.:130647-17-5
Molecular Formula:C₁₆H₂₉NOSi
Molecular Weight:279.498
Hs Code.:
DSSTox Substance ID:DTXSID001345122

Synonyms:SCHEMBL9139051;DTXSID001345122;(1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine;130647-17-5

Suppliers and Price of (1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:279.201841083
Heavy Atom Count:19
Complexity:266

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O[Si](C)(C)C(C)(C)C)NC
Isomeric SMILES:C[C@@H]([C@@H](C1=CC=CC=C1)O[Si](C)(C)C(C)(C)C)NC

Technology Process of (1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine

There total 5 articles about (1R,2S)-1-{[tert-Butyl(dimethyl)silyl]oxy}-N-methyl-1-phenylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130647-17-5
(1R,2S)-(-)-2-(methylamino)-1-phenyl-1<(tert-butyldimethylsilyl)oxy>-propane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 48h; Heating;
DOI:10.1016/S0040-4020(03)00975-X

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 69739-34-0
t-butyldimethylsiyl triflate

: 130647-17-5
(1R,2S)-(-)-2-(methylamino)-1-phenyl-1<(tert-butyldimethylsilyl)oxy>-propane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 0.5h; cooling;
DOI:10.1021/jo049365i

Reference yield:

: 120390-75-2
(R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-benzeneacetonitrile

: 130647-17-5
(1R,2S)-(-)-2-(methylamino)-1-phenyl-1<(tert-butyldimethylsilyl)oxy>-propane

Guidance literature:: Multi-step reaction with 2 steps

1: 1) ether, 4 h, reflux 2) methanol, 30 min, r.t.

2: NaBH₄ / methanol; diethyl ether / Ambient temperature

With sodium tetrahydroborate; In methanol; diethyl ether;