(S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

Base Information

Chemical Name:(S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate
CAS No.:1412886-07-7
Molecular Formula:C₂₆H₃₁N₃O₄
Molecular Weight:449.55
Hs Code.:

Synonyms:(S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

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Chemical Property of (S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

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Technology Process of (S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

There total 3 articles about (S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1186288-90-3
C₂₁H₂₂N₂O₂

: 145937-64-0
(R)-serine ethyl ester

: 1412886-07-7
(S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

Guidance literature:: C₂₁H₂₂N₂O₂; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.5h; Cooling with ice;

(R)-serine ethyl ester; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.09.032

Reference yield:

: 13599-12-7
ethyl 3-phenyl-1H-pyrazole-5-carboxylate

: 1412886-07-7
(S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile

2.1: water; potassium hydroxide

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / Cooling with ice

3.2: 1 h / 20 °C

With water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.09.032

Reference yield:

: C₁₇H₁₃N₂OOC₂H₅C₄H₈

: 1412886-07-7
(S)-ethyl 2-(1-(4-(tert-butyl)benzyl)-3-phenyl-1H-pyrazole-5-carboxamido)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; potassium hydroxide

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / Cooling with ice

2.2: 1 h / 20 °C

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In dichloromethane;
DOI:10.1016/j.bmcl.2012.09.032