5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 13599-12-7
• Molecular Formula: C19H22ClN3O
• Molecular Weight: 216.239
• Hs Code.: 2933199090
• Mol file: 13599-12-7.mol

Synonyms:SALOR-INT L250031-1EA;5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE;1H-pyrazole-5-carboxylic acid, 3-phenyl-, ethyl ester

Chemical Property of 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 1.58E-07mmHg at 25°C
• Boiling Point: 427.9°C at 760 mmHg
• Flash Point: 212.6°C
• PSA: 54.98000
• Density: 1.196g/cm³
• LogP: 2.25340
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl3-phenylpyrazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

There total 14 articles about 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diazoacetic acid ethyl ester (623-73-4) + phenylacetylene (536-74-3) → ethyl 3-phenyl-1H-pyrazole-5-carboxylate (13599-12-7)

Guidance literature:

at 120 ℃; for 0.166667h; microwave irradiation;

DOI:10.3987/COM-06-10803

Reference yield: 95.0%

→ ethyl 3-phenyl-1H-pyrazole-5-carboxylate (13599-12-7)

Guidance literature:

Reference yield: 91.0%

ethanol (64-17-5) + 1,1,1-trichloro-4-methoxy-4-phenyl-3-buten-2-one → ethyl 3-phenyl-1H-pyrazole-5-carboxylate (13599-12-7)

Guidance literature:

With hydrazine hydrochloride; for 4h; Heating;

DOI:10.1055/s-1995-4147

upstream raw materials:

ethanol

ethyl 2,4-dioxo-4-phenylbutyrate

diazoacetic acid ethyl ester

phenylacetylene

Downstream raw materials:

2-ethyl-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester

4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3-methoxy-benzyl)-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester

4-benzo[1,3]dioxol-5-ylmethyl-2-(3-methoxy-benzyl)-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester

4-bromo-2-(3-methoxy-benzyl)-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester

Refernces

• 1、 Kamal, Ahmed,Shaik, Anver Basha,Polepalli, Sowjanya,Santosh Reddy, Vangala,Bharath Kumar,Gupta, Soma,Rama Krishna,Nagabhushana, Ananthamurthy,Mishra, Rakesh K.,Jain, Nishant. "Pyrazole-oxadiazole conjugates: Synthesis, antiproliferative activity and inhibition of tubulin polymerization". . p. 7993 - 8007. Retrieved 2014.
• 2、 Goulioukina, Nataliya S.,Makukhin, Nikolay N.,Shinkarev, Egor D.,Grishin, Yuri K.,Roznyatovsky, Vitaly A.,Beletskaya, Irina P.. "Base mediated 1,3-dipolar cycloaddition of α-substituted vinyl phosphonates with diazo compounds for synthesis of 3-pyrazolylphosphonates and 5-pyrazolcarboxylates". . p. 10000 - 10010. Retrieved 2016.
• 3、 -. "PIKFYVE KINASE INHIBITORS". Page/Page column 201; 200. . Retrieved 2021/08/20.
• 4、 Ma, Liyao,Ou, Pengcheng,Huang, Xueliang. "Divergent synthesis of 1,3,5-tri and 1,3-disubstituted pyrazoles under transition metal-free conditions". supporting information. p. 6487 - 6491. Retrieved 2020/11/10.