3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

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Chemical Name:3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide
CAS No.:1354546-73-8
Molecular Formula:C₂₂H₂₇NO₅S₂
Molecular Weight:449.592
Hs Code.:

Synonyms:3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

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Chemical Property of 3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

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Technology Process of 3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

There total 4 articles about 3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1354546-72-7
3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)propanoic acid

: 1354546-73-8
3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

Guidance literature:: 3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)propanoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 2-methyltetrahydrofuran; for 1h;

O-2-tetrahydro-2H-pyranhydroxylamine; In 2-methyltetrahydrofuran; at 20 ℃;
DOI:10.1021/jm2014748

Reference yield:

: 1354546-71-6
ethyl 3-[(4-bromophenyl)thio]-2-methyl-2-(methylsulfonyl)propanoate

: 1354546-73-8
3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 80 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h

3.2: 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; potassium carbonate; sodium hydroxide; In 2-methyltetrahydrofuran; 1,4-dioxane; water; 1.1: Suzuki-Miyaura coupling;
DOI:10.1021/jm2014748

Reference yield:

: 1354546-31-8
ethyl 3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)propanoate

: 1354546-73-8
3-(biphenyl-4-ylthio)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h

2.2: 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium hydroxide; In 2-methyltetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm2014748