methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

Base Information

Chemical Name:methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride
CAS No.:1399844-83-7
Molecular Formula:C₃₁H₂₉N₅O₄*ClH
Molecular Weight:572.063
Hs Code.:

Synonyms:methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

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Chemical Property of methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

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Technology Process of methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

There total 12 articles about methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1399844-82-6
((2S,5S)-2-{5-[4'-(2-tert-butoxycarbonylamino-acetyl)-biphenyl-4-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

: 1399844-83-7
methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 3h;

Reference yield:

: 204326-24-9
(2S,11S)-11-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-12-oxo-1-azatricyclo[6.4.1.0^[4,13]]trideca-4⁽¹³⁾,5,7-triene-2-carboxylic acid

: 1399844-83-7
methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 16 h / 80 °C / Sealed tube; Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

With piperidine; hydrogenchloride; ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; xylene;

Reference yield:

: 1399843-77-6
(2S,5S)-5-(methoxycarbonylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid

: 1399844-83-7
methyl (2S,5S)-2-(5-(4'-(2-amino acetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 16 h / 80 °C / Sealed tube; Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; ammonium acetate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; acetonitrile; xylene;