methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Base Information

Chemical Name:methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate
CAS No.:1399845-51-2
Molecular Formula:C₃₁H₂₉N₅O₄
Molecular Weight:535.602
Hs Code.:

Synonyms:methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

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Chemical Property of methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

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Technology Process of methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

There total 12 articles about methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1399844-82-6
((2S,5S)-2-{5-[4'-(2-tert-butoxycarbonylamino-acetyl)-biphenyl-4-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

: 1399845-51-2
methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 204326-24-9
(2S,11S)-11-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-12-oxo-1-azatricyclo[6.4.1.0^[4,13]]trideca-4⁽¹³⁾,5,7-triene-2-carboxylic acid

: 1399845-51-2
methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

2: sodium hydroxide; sodium carbonate / water / 3 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonium acetate / xylene / 3 h / 140 °C / Inert atmosphere; Sealed tube

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 16 h / 80 °C / Sealed tube; Inert atmosphere

6: trifluoroacetic acid / dichloromethane

With piperidine; ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; xylene;

Reference yield:

: 5467-72-1
α-amino-4-bromoacetophenone hydrochloride

: 1399845-51-2
methyl (2S,5S)-2-(5-(4'-(2-aminoacetyl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

2: potassium acetate / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 16 h / 80 °C / Sealed tube; Inert atmosphere

4: trifluoroacetic acid / dichloromethane

With potassium acetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;