3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione

Base Information

• Chemical Name: 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione
• CAS No.: 137043-31-3
• Molecular Formula: C₂₆H₃₄N₂O₈
• Molecular Weight: 502.565
• Mol file: 137043-31-3.mol

Synonyms:3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione

Chemical Property of 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione

There total 10 articles about 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione (137043-30-2) → 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6β)-piperazinedione (137043-31-3) + 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione (137043-31-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 50 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

(3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione (137043-30-2) → 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6β)-piperazinedione (137043-31-3) + 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6α)-piperazinedione (137043-31-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 50 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

2,4,5-trimethoxy-3-methylbenzaldehyde (60059-09-8) → 3,6-Bis-(2,4,5-trimethoxy-3-methylphenyl)methyl-(3α,6β)-piperazinedione (137043-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64.3 percent / Cs₂CO₃ / dimethylformamide / 3 h / 80 °C

2: H₂ / 10percent Pd/C / acetic acid / 3 h / 50 °C

With hydrogen; caesium carbonate; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86518-2

upstream raw materials:

(3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione

2,4,5-trimethoxy-3-methylbenzaldehyde

1-Hydroxymethyl-2,4,5-trimethoxy-3-methylbenzene

2,4-Dimethoxy-3-methyl-5-acetoxymethylphenol

Downstream raw materials:

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-7,9,10-trimethoxy-8,11-dimethyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine