2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Base Information

Chemical Name:2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine
CAS No.:137043-33-5
Molecular Formula:C₂₇H₃₃ClN₂O₈
Molecular Weight:549.021
Hs Code.:

2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Synonyms:2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Chemical Property of 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Technology Process of 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

There total 6 articles about 2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 137023-16-6
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

: 137043-33-5
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: With tert-butylhypochlorite; potassium tert-butylate; In toluene; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: 137023-08-6
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-(phenyl)methyl-4-oxo-7,9,10-trimethoxy-8-methyl-11-(phenyl)methyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

: 137043-33-5
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / 10percentPd/C / methanol / 6 h / Ambient temperature

2: 77 percent / Na, ammonia / tetrahydrofuran; ethanol / 1 h / -78 °C

3: 100 percent / potassium tert-butoxide, tert-butyl hypochlorite / toluene / 3 h / Ambient temperature

With tert-butylhypochlorite; potassium tert-butylate; ammonia; sodium; 10% palladium on active carbon; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1016/S0040-4020(01)86518-2

Reference yield:

: (3R,6R)-1,4-Dibenzyl-5-hydroxy-3,6-bis-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazin-2-one

: 137043-33-5
2-(3-Methyl-2,4,5-trimethoxyphenyl)methyl-3-chloro-4-oxo-7,9,10-trimethoxy-8-methyl-11-formyl-(1α,2β,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 4 steps

1: CF₃CO₂H / 36 h / Heating

2: 67 percent / 10percentPd/C / methanol / 6 h / Ambient temperature

3: 77 percent / Na, ammonia / tetrahydrofuran; ethanol / 1 h / -78 °C

4: 100 percent / potassium tert-butoxide, tert-butyl hypochlorite / toluene / 3 h / Ambient temperature

With tert-butylhypochlorite; potassium tert-butylate; ammonia; sodium; trifluoroacetic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1016/S0040-4020(01)86518-2