2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

Base Information

Chemical Name:2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid
CAS No.:1001124-86-2
Molecular Formula:C₁₇H₂₂ClNO₄
Molecular Weight:339.819
Hs Code.:

Synonyms:2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

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Chemical Property of 2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

Chemical Property:

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Technology Process of 2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

There total 7 articles about 2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189802-79-6
tert-butyl 1-(1-(4-chlorophenyl)-3-oxopropan-2-yl)cyclopropylcarbamate

: 1001124-86-2
2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

Guidance literature:: With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 0 - 20 ℃; for 2h;

Reference yield:

: 1001124-77-1
3-(tert-butyldimethylsilyloxy)-2-(4-chlorobenzyl)propanenitrile

: 1001124-86-2
2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 1 h / 20 °C

1.2: 1 h

2.1: dmap; triethylamine / tetrahydrofuran / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: pyridine-SO₃ complex / dichloromethane; dimethyl sulfoxide / 1.17 h / -15 - 0 °C

5.1: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 0 - 20 °C

With titanium(IV) isopropylate; dmap; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1001124-80-6
l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

: 1001124-86-2
2-(1-(tert-butoxycarbonylamino)cyclopropyl)-3-(4-chlorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / tetrahydrofuran / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: pyridine-SO₃ complex / dichloromethane; dimethyl sulfoxide / 1.17 h / -15 - 0 °C

4: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 0 - 20 °C

With dmap; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;