l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

Base Information

Chemical Name:l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine
CAS No.:1001124-80-6
Molecular Formula:C₁₈H₃₀ClNOSi
Molecular Weight:339.981
Hs Code.:

Synonyms:l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

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Chemical Property of l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

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Technology Process of l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

There total 3 articles about l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1001124-77-1
3-(tert-butyldimethylsilyloxy)-2-(4-chlorobenzyl)propanenitrile

: 925-90-6
ethylmagnesium bromide

: 1001124-80-6
l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

Guidance literature:: 3-(tert-butyldimethylsilyloxy)-2-(4-chlorobenzyl)propanenitrile; ethylmagnesium bromide; With titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; for 1h;

With sodium hydroxide; water; In tetrahydrofuran; diethyl ether;

Reference yield:

: 2286-53-5
3-(4-chlorophenyl)-2-(hydroxymethyl)propanenitrile

: 1001124-80-6
l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 1 h / 20 °C

2.2: 1 h

With 1H-imidazole; titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 2286-35-3
ethyl 3-(4-chlorophenyl)-2-cyanoacrylate

: 1001124-80-6
l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / isopropyl alcohol / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

3.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 1 h / 20 °C

3.2: 1 h

With 1H-imidazole; titanium(IV) isopropylate; sodium tetrahydroborate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol;