tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

Base Information

Chemical Name:tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate
CAS No.:1001124-84-0
Molecular Formula:C₁₇H₂₄ClNO₃
Molecular Weight:325.835
Hs Code.:

Synonyms:tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

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Chemical Property of tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

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Technology Process of tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

There total 5 articles about tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1001124-82-8
tert-butyl 1-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropylcarbamate

: 1001124-84-0
tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1001124-80-6
l-(1-(tert-butyldimethylsilyloxy)-3-(4-chlorophenyl)propan-2-yl)cyclopropanamine

: 1001124-84-0
tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / tetrahydrofuran / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;

Reference yield:

: 1001124-77-1
3-(tert-butyldimethylsilyloxy)-2-(4-chlorobenzyl)propanenitrile

: 1001124-84-0
tert-butyl 1-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)cyclopropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran; diethyl ether / 1 h / 20 °C

1.2: 1 h

2.1: dmap; triethylamine / tetrahydrofuran / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With titanium(IV) isopropylate; dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; diethyl ether;