2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

Base Information

Chemical Name:2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane
CAS No.:1246443-49-1
Molecular Formula:C₂₀H₂₅ClN₂O₃S
Molecular Weight:408.949
Hs Code.:

Synonyms:2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

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Chemical Property of 2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

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Technology Process of 2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

There total 2 articles about 2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1246443-46-8
2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

: 105827-91-6
α-Cl-β-thiazolyl chloride

: 1246443-49-1
2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

Guidance literature:: With sodium hydride; tetrabutylammomium bromide; In toluene; at 10 ℃; Reflux;

Reference yield:

: 39742-60-4
1-(2-phenylethyl)-4-piperidinone

: 1246443-49-1
2-(((2-chloro-5-thiazolyl)methoxy)methyl)-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / toluene

1.2: 14 h / 115 °C

2.1: sodium hydride / toluene / 28 °C

2.2: 10 °C / Reflux

With hydrogenchloride; sodium hydride; In toluene;