105827-91-6Relevant articles and documents
Synthesis, characterization and crystal structure of n-(3-((2-chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide
He, Jian-Ling,Cheng, Wei-Hua
, p. 2383 - 2385 (2015)
N-(3-[(2-chlorothiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide (I), i.e., thiamethoxam, it is a broad-spectrum insecticide that effectively controls insects, being a second generation neonicotinoid compound belonging to the chemical subclass the thianicotinyls. It was prepared from 5-(chloromethyl)-2-(phenylthio)thiazole (1) via chlorination by Cl2/HCl system and then condensation by K2CO3/CsI. The product was characterized by NMR and LC-MS. The crystal structure of compound I was investigated using X-ray diffraction and SHELXTL-97 software. The result indicated that compound I crystallized in the monoclinic system, space group P 21/n with a = 6.488(13), b = 28.786 (6), c = 6.804(14) ?, V=1225.1 (5) ?3; Z4.
Continuous production process of 2-chloro-5-chloromethylthiazole
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Paragraph 0049-0072, (2021/10/27)
The invention provides a continuous production process of 2-chloro-5-chloromethylthiazole, which comprises the following steps of providing an organic solvent, and mixing a raw material 2-chloro-3-isothiocyano-1-propylene into the organic solvent to form a mixed solution, providing a continuous chlorination device, introducing chlorine into the device, and carrying out chlorination reaction, providing a rectification device, and sequentially carrying out solvent distillation removal, light component distillation removal and heavy component removal rectification in a vacuum state to obtain a 2-chloro-5-chloromethylthiazole product. The chlorination reaction is carried out in a continuous feeding and continuous overflowing manner; and the rectification device adopts the operation conditions of continuous feeding and continuous vacuum rectification. According to the process, the content of 2-chloro-5-chloromethylthiazole is increased to 99% or above, the content of by-products is reduced by 0.5% or below, the yield is increased to 91% or above, continuous production is safe and controllable, the generation amount of by-products and wastes is small, the product quality is stable, and green, environment-friendly and safe industrial production is achieved.
Synthesis process of 2-chloro-5-chloromethylthiazole
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Paragraph 0032-0039, (2021/07/17)
The invention discloses a synthesis process of 2-chloro-5-chloromethylthiazole, and relates to the technical field of synthesis of 2-chloro-5-chloromethylthiazole. The method comprises the following steps: adding excessive sodium thiocyanate, water and a catalyst C2 into a reactor, slowly adding 2, 3-dichloropropene under the conditions of ultrasonic shearing and stirring, stopping ultrasonic treatment after the addition is completed, keeping stirring, slowly heating the mixed solution to reflux, and keeping the temperature until the reaction is complete; stopping stirring after the reaction is completed, carrying out primary standing layering, separating and transferring a primary organic layer into a distillation kettle after complete layering, stirring the residual solution, carrying out ultrasonic uniform mixing, carrying out secondary standing layering, separating and transferring a secondary organic layer into the distillation kettle after complete layering, and carrying out reduced pressure distillation to obtain an intermediate product; and adding the intermediate product and trichloromethane into a reactor, stirring at normal temperature, slowly dropwise adding sufficient sulfuryl chloride, and stirring at 45-55 DEG C until the reaction is complete after dropwise adding. The method is simple in process, low in raw material cost and high in product yield.