1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione

Base Information

Chemical Name:1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione
CAS No.:1334865-57-4
Molecular Formula:C₁₉H₁₁FN₄O₃S
Molecular Weight:394.386
Hs Code.:

Synonyms:1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione

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Chemical Property of 1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione

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Technology Process of 1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione

There total 2 articles about 1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 79-37-8
oxalyl dichloride

: 1296214-86-2
1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]urea

: 1334865-57-4
1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.3390/molecules16097565

Reference yield:

: (R)-1-(6-fluorobenzothiazol-2-yl)ethylamine 4-methylbenzenesulfonate

: 40465-45-0
p-cyanophenyl isocyanate

: 1334865-57-4
1-(4-cyanophenyl)-3-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]imidazolidine-2,4,5-trione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / toluene / 20 °C

2: dichloromethane / 3 h / 0 - 20 °C

With sodium hydroxide; In dichloromethane; toluene;
DOI:10.3390/molecules16097565