(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Base Information

Chemical Name:(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate
CAS No.:1218770-06-9
Molecular Formula:C₃₈H₄₂N₂O₅S
Molecular Weight:638.828
Hs Code.:

Synonyms:(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Suppliers and Price of (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

There total 9 articles about (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1489278-85-4
(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxoprop-1-enyl)-5-phenylthiazol-2-yl)ethylcarbamate

: 107905-52-2
ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate

: 1218770-06-9
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxoprop-1-enyl)-5-phenylthiazol-2-yl)ethylcarbamate; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489278-51-4
C₃₀H₃₂N₂O₄S

: 1218770-06-9
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

2.2: 4 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

5.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

5.2: 2 h / -78 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; potassium hexamethylsilazane; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: C₃₃H₃₆N₂O₄S

: 1218770-06-9
(2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C

2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

With 18-crown-6 ether; potassium hexamethylsilazane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1016/j.ejmech.2013.09.017