(2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

Base Information

Chemical Name:(2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol
CAS No.:1432518-78-9
Molecular Formula:C₁₉H₂₁FO₄S
Molecular Weight:364.438
Hs Code.:

Synonyms:(2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

Chemical Property:

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Technology Process of (2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

There total 11 articles about (2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1432519-35-1
(2Z)-2-({2-[2,2-bis(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

: 1432518-78-9
(2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 2.5h; Cooling with ice;
DOI:10.1039/c3ob40115d

Reference yield:

: C₂₃H₂₃FO₂S₂

: 1432518-78-9
(2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

2: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

3: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 7 h / 0 °C / Cooling with ice

5: caesium carbonate / tetrahydrofuran / 1.33 h / 0 - 20 °C / Cooling with ice

6: diisobutylaluminium hydride / toluene / 2.33 h / -78 - 0 °C / Cooling with ice

7: sodium amalgam; disodium hydrogenphosphate / methanol / 2.5 h / 0 °C / Cooling with ice

With pyridine; hydrogenchloride; dmap; disodium hydrogenphosphate; n-butyllithium; diphenyl diselenide; sodium amalgam; diisobutylaluminium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;
DOI:10.1039/c3ob40115d

Reference yield:

: 77532-79-7
3-fluoro-6-methylbenzonitrile

: 1432518-78-9
(2Z)-2-({2-[2-(benzenesulfonyl)ethyl]-5-fluorophenyl}methyl)but-2-ene-1,4-diol

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane

2.1: diisobutylaluminium hydride; hydrogen bromide / dichloromethane / Cooling with ice

3.1: toluene-4-sulfonic acid / methanol / 1 h / 50 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - 0 °C / Cooling with ice

4.2: 0.67 h / -78 - 0 °C / Cooling with ice

5.1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

6.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

7.1: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 7 h / 0 °C / Cooling with ice

9.1: caesium carbonate / tetrahydrofuran / 1.33 h / 0 - 20 °C / Cooling with ice

10.1: diisobutylaluminium hydride / toluene / 2.33 h / -78 - 0 °C / Cooling with ice

11.1: sodium amalgam; disodium hydrogenphosphate / methanol / 2.5 h / 0 °C / Cooling with ice

With pyridine; hydrogenchloride; dmap; disodium hydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); diphenyl diselenide; sodium amalgam; hydrogen bromide; diisobutylaluminium hydride; caesium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; toluene;
DOI:10.1039/c3ob40115d