2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

Base Information

Chemical Name:2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine
CAS No.:1253847-64-1
Molecular Formula:C₂₇H₃₇N₇O₅S
Molecular Weight:571.701
Hs Code.:

Synonyms:2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

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Chemical Property of 2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

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Technology Process of 2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

There total 9 articles about 2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 4530-20-5
BOC-glycine

: 1253847-02-7
2-(3-amino-4-methoxybenzylsulfanyl)-8-ethyl-9-methyl-6-morpholino-9H-purine

: 1253847-64-1
2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1253847-01-6
8-ethyl-2-(4-methoxybenzylsulfanyl)-9-methyl-6-morpholino-9H-purine

: 1253847-64-1
2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / methoxybenzene / 80 °C

1.2: Cooling with ice

2.1: hydrogen / palladium on activated charcoal / dichloromethane; methanol / 18 h / 760.05 Torr

3.1: dicyclohexyl-carbodiimide / dichloromethane / 4 h / 20 °C

With hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; methoxybenzene;

Reference yield:

: 869119-60-8
4-chloro-2-(4-methoxybenzylsulfanyl)-6-methylaminopyrimidine

: 1253847-64-1
2-[3-(2-tert-butoxycarbonylaminoacetylamino)-4-methoxybenzyl sulfanyl]-8-ethyl-9-methyl-6-morpholino-9H-purine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 80 °C

2.1: sodium nitrite; acetic acid / water / 5 h / 20 °C

2.3: 4 h / 760.05 Torr

3.1: methanol / 3 h / 20 °C

4.1: trifluoroacetic acid / methoxybenzene / 80 °C

4.2: Cooling with ice

5.1: hydrogen / palladium on activated charcoal / dichloromethane; methanol / 18 h / 760.05 Torr

6.1: dicyclohexyl-carbodiimide / dichloromethane / 4 h / 20 °C

With hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane; water; methoxybenzene;