1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Base Information

Chemical Name:1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea
CAS No.:1261161-58-3
Molecular Formula:C₂₄H₂₃ClN₂O₂
Molecular Weight:406.912
Hs Code.:

Synonyms:1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

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Chemical Property of 1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

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Technology Process of 1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

There total 3 articles about 1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1256930-30-9
(+/-)-1-(1-(4-chlorophenyl)-1-phenylallyl)-1-(4-methoxyphenyl)-3-methylurea

: 1261161-58-3
1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Guidance literature:: (+/-)-1-(1-(4-chlorophenyl)-1-phenylallyl)-1-(4-methoxyphenyl)-3-methylurea; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

With methanol; In N,N-dimethyl-formamide; chemoselective reaction; Inert atmosphere;
DOI:10.1039/c2cc38704b

Reference yield:

: C₂₃H₂₁ClN₂O₂

: 74-88-4
methyl iodide

: 1261161-58-3
1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Guidance literature:: C₂₃H₂₁ClN₂O₂; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol102155h

Reference yield:

: 104-12-1
p-chlorphenylisocyanate

: 104937-84-0
N-(p-methoxyphenyl)-α-ethenylbenzenemethaneamine

: 1261161-58-3
1-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/ol1027442