methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

Base Information

Chemical Name:methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate
CAS No.:1312467-80-3
Molecular Formula:C₃₇H₅₂O₇
Molecular Weight:608.816
Hs Code.:

Synonyms:methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

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Chemical Property of methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

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Technology Process of methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

There total 4 articles about methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 14772-99-7
3-oxo cholic acid methyl ester

: 98-88-4
benzoyl chloride

: 1312467-81-4
methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(R)]tetrahydropyranyloxy-5β-cholan-24-oate

: 1312467-80-3
methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

: 1312467-85-8
methyl 3-oxo-12α-benzoyloxy-7α-O-[2’(R)]tetrahydropyranyloxy-5β-cholan-24-oate

: 1312467-84-7
methyl 3-oxo-12α-benzoyloxy-7α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

Guidance literature:: 3,4-dihydro-2H-pyran; 3-oxo cholic acid methyl ester; With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 12h;

benzoyl chloride; With pyridine; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1021/jm501676v

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 14772-99-7
3-oxo cholic acid methyl ester

: 98-88-4
benzoyl chloride

: 1312467-81-4
methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(R)]tetrahydropyranyloxy-5β-cholan-24-oate

: 1312467-80-3
methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

Guidance literature:: 3,4-dihydro-2H-pyran; 3-oxo cholic acid methyl ester; With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 12h;

benzoyl chloride; With pyridine; at 20 ℃; for 144h;

Reference yield:

: 81-25-4
cholic acid

: 1312467-81-4
methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(R)]tetrahydropyranyloxy-5β-cholan-24-oate

: 1312467-80-3
methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 3 h

2.1: silver carbonate / toluene / 12 h / Reflux

3.1: toluene-4-sulfonic acid / tetrahydrofuran / 12 h / 20 °C

3.2: 144 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; silver carbonate; In tetrahydrofuran; water; toluene;