N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

Base Information

Chemical Name:N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide
CAS No.:1347255-67-7
Molecular Formula:C₂₇H₃₁BrClN₃O₂
Molecular Weight:544.919
Hs Code.:

Synonyms:N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

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Chemical Property of N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

Chemical Property:

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Technology Process of N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

There total 4 articles about N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137730-67-7
spiro(1H-indene-1,4'-piperidine) hydrochloride

: 1347255-67-7
N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 80 °C

2: water; lithium hydroxide monohydrate / ethanol / 90 °C

3: N,N-dimethyl-formamide / 1 h / 60 °C

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1119271-25-8
C₁₀H₉BrClNO₂

: 1119271-24-7
1-(4-piperidinyl)-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethanol

: 1347255-67-7
N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield:

: 1093956-67-2
benzyl 4-(oxiran-2-yl)piperidine-1-carboxylate

: 1347255-67-7
N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 80 °C

2: water; lithium hydroxide monohydrate / ethanol / 90 °C

3: N,N-dimethyl-formamide / 1 h / 60 °C

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;