phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

Base Information

Chemical Name:phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate
CAS No.:1119271-23-6
Molecular Formula:C₂₈H₃₄N₂O₃
Molecular Weight:446.59
Hs Code.:

Synonyms:phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

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Chemical Property of phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

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Technology Process of phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

There total 1 articles about phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1093956-67-2
benzyl 4-(oxiran-2-yl)piperidine-1-carboxylate

: 137730-67-7
spiro(1H-indene-1,4'-piperidine) hydrochloride

: 1119271-23-6
phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃;

Reference yield:

: 1119271-23-6
phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

: 1119270-41-5
1-{1-[(2E)-3-(4-chlorophenyl)-2-propenoyl]-4-piperidinyl}-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / ethanol / 90 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

With lithium hydroxide monohydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

Reference yield:

: 1119271-23-6
phenylmethyl 4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxylate

: 1347255-67-7
N-(3-bromo-4-chlorophenyl)-4-[1-hydroxy-2-(1'H-spiro[indene-1,4'-piperidin]-1'-yl)ethyl]-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / ethanol / 90 °C

2: N,N-dimethyl-formamide / 1 h / 60 °C

With lithium hydroxide monohydrate; water; In ethanol; N,N-dimethyl-formamide;