ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

Base Information

Chemical Name:ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate
CAS No.:139335-18-5
Molecular Formula:C₂₀H₂₀N₂O₄S
Molecular Weight:384.456
Hs Code.:

Synonyms:ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

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Chemical Property of ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

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Technology Process of ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

There total 5 articles about ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 139335-17-4
ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-5-ylacetate

: 139335-18-5
ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.39.2837

Reference yield:

: 98-88-4
benzoyl chloride

: 139335-18-5
ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / CHCl₃ / 0.5 h / Heating

2: 92 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

3: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min

4: 93 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

With n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In chloroform;
DOI:10.1248/cpb.39.2837

Reference yield:

: 26155-37-3
phenylacetaldehyde methylthio(thiocarbonyl)hydrazone

: 139335-18-5
ethyl 3-benzoyl-2-benzyl-2,3-dihydro-1,3,4-thiadiazol-1-oxide-5-ylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / CHCl₃ / 0.5 h / Heating

2: 92 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

3: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min

4: 93 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

With n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In chloroform;
DOI:10.1248/cpb.39.2837