Technology Process of 1,3,4-Thiadiazole,
3-benzoyl-2,3-dihydro-5-(methylthio)-2-(phenylmethyl)-
There total 1 articles about 1,3,4-Thiadiazole,
3-benzoyl-2,3-dihydro-5-(methylthio)-2-(phenylmethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
chloroform;
for 0.5h;
Ambient temperature;
DOI:10.1248/cpb.39.2837
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 92 percent / m-CPBA / CHCl3 / 0.5 h / Ambient temperature
2: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min
3: 93 percent / m-CPBA / CHCl3 / 0.5 h / Ambient temperature
4: 82 percent / 4-dimethylaminopyridine (DMAP) / ethanol / 0.5 h / Heating
5: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl4 / 0.02 h / Heating
6: 92 percent / CrO3 / acetic acid / 0.5 h / 60 °C
7: 94 percent / Zn, AcOH / 0.5 h / Ambient temperature
8: 69 percent / pyridinium dichromate (PDC) / CH2Cl2 / 4 h / Ambient temperature
9: 85 percent / K2CO3 / ethanol; H2O / 2 h / 60 °C
10: Ambient temperature
With
chromium(VI) oxide; dmap; N-Bromosuccinimide; dipyridinium dichromate; n-butyllithium; potassium carbonate; acetic acid; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc;
dibenzoyl peroxide;
In
tetrachloromethane; ethanol; dichloromethane; chloroform; water; acetic acid;
DOI:10.1248/cpb.39.2837
