N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

Base Information

Chemical Name:N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide
CAS No.:105695-43-0
Molecular Formula:C₂₁H₂₈N₄O₄S
Molecular Weight:432.544
Hs Code.:

Synonyms:N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

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Technology Process of N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

There total 12 articles about N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 105695-41-8
N-cyclohexyl-N-methyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)thio>butyramide

: 105695-43-0
N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at -10 - 20 ℃;
DOI:10.1021/jm00385a012

Reference yield:

: 100-60-7
N-methylcyclohexylamine

: 105695-43-0
N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: cyclohexadiene / 10percent Pd/C / ethanol / 48 h / Heating

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, 24 h 2.) EtOH

6: 91 percent / m-chloroperbenzoic acid (m-CPBA) / CHCl₃ / -10 - 20 °C

With ammonium hydroxide; sodium acetate; sodium cyanoborohydride; sodium carbonate; cyclohexa-1,3-diene; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00385a012

Reference yield:

: 69-78-3
5,5'-dithiobis-(2-nitrobenzoic acid)

: 105695-43-0
N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazoline-7-sulfonyl)-butyramide

Guidance literature:: Multi-step reaction with 11 steps

1: 80 percent / Me₂S*BH₃ / 1,2-dimethoxy-ethane / 3 h / Heating

2: 46 percent / DBU / tetrahydrofuran

3: 73 percent / pyridinium dichromate (PDC) / CH₂Cl₂

4: 99 percent / aq. HCl / dioxane / 2 h / Heating

5: oxalyl chloride / benzene; dimethylformamide / 0.5 h

6: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

7: 1.) AcONa / ethanol / 0.5 h

8: NaBH₃CN / ethanol / 3 h

9: cyclohexadiene / 10percent Pd/C / ethanol / 48 h / Heating

10: 2.) conc. aq. NH₃ / 1.) EtOH, RT, 24 h 2.) EtOH

11: 91 percent / m-chloroperbenzoic acid (m-CPBA) / CHCl₃ / -10 - 20 °C

With hydrogenchloride; ammonium hydroxide; dipyridinium dichromate; oxalyl dichloride; dimethylsulfide borane complex; sodium acetate; sodium cyanoborohydride; sodium carbonate; cyclohexa-1,3-diene; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a012