4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

Base Information

Chemical Name:4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether
CAS No.:342900-30-5
Molecular Formula:C₂₀H₂₇BrOSSi
Molecular Weight:423.489
Hs Code.:

Synonyms:4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

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Chemical Property of 4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

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Technology Process of 4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

There total 3 articles about 4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 882-33-7
diphenyldisulfane

: 342900-29-2
4-bromo-3-(2-hydroxyethyl)phenyl tert-butyldimethylsilyl ether

: 342900-30-5
4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

Guidance literature:: With tributylphosphine; In benzene; at 20 ℃; for 8h;
DOI:10.1021/ja0035811

Reference yield:

: 245442-82-4
ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate

: 342900-30-5
4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Br₂; AcOH; KOAc / 2.5 h / 15 - 17 °C

2: 93 percent / LiAlH₄ / diethyl ether / 1.17 h / 0 °C

3: 76 percent / tributyl phosphine / benzene / 8 h / 20 °C

With lithium aluminium tetrahydride; tributylphosphine; bromine; potassium acetate; acetic acid; In diethyl ether; benzene;
DOI:10.1021/ja0035811

Reference yield:

: 342900-28-1
ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate

: 342900-30-5
4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / LiAlH₄ / diethyl ether / 1.17 h / 0 °C

2: 76 percent / tributyl phosphine / benzene / 8 h / 20 °C

With lithium aluminium tetrahydride; tributylphosphine; In diethyl ether; benzene;
DOI:10.1021/ja0035811