ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate

Base Information

• Chemical Name: ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate
• CAS No.: 342900-28-1
• Molecular Formula: C₁₆H₂₅BrO₃Si
• Molecular Weight: 373.362
• Mol file: 342900-28-1.mol

Synonyms:ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate

Chemical Property of ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate

There total 1 articles about ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate (245442-82-4) → ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate (342900-28-1)

Guidance literature:

With bromine; potassium acetate; acetic acid; at 15 - 17 ℃; for 2.5h;

DOI:10.1021/ja0035811

Reference yield: 93.0%

ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate (342900-28-1) → 4-bromo-3-(2-hydroxyethyl)phenyl tert-butyldimethylsilyl ether (342900-29-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 1.16667h;

DOI:10.1021/ja0035811

Reference yield:

ethyl 6-bromo-3-(tert-butyldimethylsilyloxy)phenyl acetate (342900-28-1) + cyclopropylboronic acid (411235-57-9) → [5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopropyl-phenyl]-acetic acid ethyl ester (936758-49-5)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃;

upstream raw materials:

ethyl 3-(tert-butyldimethylsilyloxy)phenyl acetate

Downstream raw materials:

4-bromo-3-(2-hydroxyethyl)phenyl tert-butyldimethylsilyl ether

4-bromo-3-[2-(phenylthio)ethyl]phenyl tert-butyldimethylsilyl ether

[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopropyl-phenyl]-acetic acid ethyl ester