2,4-dichloro-5-fluorobenzoylacetic acid

Base Information

• Chemical Name: 2,4-dichloro-5-fluorobenzoylacetic acid
• CAS No.: 111760-50-0
• Molecular Formula: C₉H₅Cl₂FO₃
• Molecular Weight: 251.041
• Mol file: 111760-50-0.mol

Synonyms:2,4-dichloro-5-fluorobenzoylacetic acid

Chemical Property of 2,4-dichloro-5-fluorobenzoylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-5-fluorobenzoylacetic acid

There total 1 articles about 2,4-dichloro-5-fluorobenzoylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-5-fluoroacetophenone (704-10-9) + methyl magnesium carbonate → 2,4-dichloro-5-fluorobenzoylacetic acid (111760-50-0)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 1h; Yield given;

Reference yield:

2,4-dichloro-5-fluorobenzoylacetic acid (111760-50-0) + orthoformic acid triethyl ester (122-51-0) + 4-fluoroaniline (371-40-4) → (Z)-2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxobenzenepropanoic acid, ethyl ester

Guidance literature:

With acetic anhydride; In ethanol; hexane;

Reference yield:

2,4-dichloro-5-fluorobenzoylacetic acid (111760-50-0) → methyl-2,4-dichloro-5-fluoro-α-(4-fluoro-2-methylphenylhydrazono)benzoylacetate (129527-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl(gas) / methanol / 20 h / Ambient temperature

2: 1.) NaNO₂, aq. HCl, 2.) potassium acetate / 1.) 0 deg C, 30 min, 2.) water, methanol, dioxane, a) 5 deg C, 30 min, b) RT, 2 h

With hydrogenchloride; potassium acetate; sodium nitrite; In methanol;

upstream raw materials:

2,4-dichloro-5-fluoroacetophenone

Downstream raw materials:

methyl 2,4-dichloro-5-fluoro-benzoylacetate

7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid

7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid

methyl 2,4-dichloro-5-fluoro-α-(4-fluorophenylhydrazono)benzoylacetate

Refernces