2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 108012-55-1
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288
• Mol file: 108012-55-1.mol

Synonyms:2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 4 articles about 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

vanillin (121-33-5,8014-42-4) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (108012-55-1)

Guidance literature:

With α-chymotrypsin; In ethanol; at 60 ℃; for 0.5h; Green chemistry; Enzymatic reaction;

DOI:10.1016/j.cclet.2016.06.001

Reference yield: 84.0%

isatoic anhydride (118-48-9) + vanillin (121-33-5,8014-42-4) → 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (108012-55-1)

Guidance literature:

With ammonium acetate; Thiamine hydrochloride; In ethanol; for 5h; Reflux;

DOI:10.1016/j.tetlet.2012.08.090

Reference yield: 60.0%

benzamide (55-21-0,27208-38-4) + vanillin (121-33-5,8014-42-4) → 2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (108012-55-1)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2010.12.004

upstream raw materials:

N-vanillyliden-anthranilic acid amide

benzamide

vanillin

anthranilic acid amide

Downstream raw materials:

2-(4-(4-bromobutoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

2-(4-(5-bromopentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

2-(4-(3-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazol-3-yl)phenoxy)propoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

2-(4-(4-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazol-3-yl)phenoxy)butoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one