(2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

Base Information

Chemical Name:(2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid
CAS No.:1316755-69-7
Molecular Formula:C₂₆H₄₀F₃NO₂
Molecular Weight:455.604
Hs Code.:

Synonyms:(2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

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Chemical Property of (2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

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Technology Process of (2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

There total 8 articles about (2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1316757-08-0
diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

: 1316755-69-7
(2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

: 1316755-68-6
(2R)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

Guidance literature:: diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate; With water; sodium hydroxide; In ethanol; at 110 ℃; for 7h;

With sodium hydrogen sulfate; In ethanol; water; pH=4;

Reference yield:

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 1316755-69-7
(2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

: 1316755-68-6
(2R)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 1.5 h / -78 °C

1.2: 0.17 h

2.1: L-Selectride / tetrahydrofuran / 18 h / -78 - 20 °C

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

4.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C

4.2: 36 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h

7.2: 5 h

8.1: sodium hydroxide; water / ethanol / 7 h / 110 °C

8.2: pH 4

With copper(I) bromide dimethylsulfide complex; water; L-Selectride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; mineral oil;

Reference yield:

: 1316757-06-8
diethyl ((1R,3S,4R)-4-amino-3-[4-(trifluoromethyl)phenyl]cyclohexyl)malonate

: 1316755-69-7
(2S)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

: 1316755-68-6
(2R)-2-{(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h

2.2: 5 h

3.1: sodium hydroxide; water / ethanol / 7 h / 110 °C

3.2: pH 4

With water; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; mineral oil;