diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Base Information

Chemical Name:diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate
CAS No.:1316757-08-0
Molecular Formula:C₃₁H₄₈F₃NO₄
Molecular Weight:555.722
Hs Code.:

Synonyms:diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Suppliers and Price of diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

There total 8 articles about diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1316757-07-9
diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

: 74-88-4
methyl iodide

: 1316757-08-0
diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Guidance literature:: diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate; With sodium hydride; In tetrahydrofuran; mineral oil; for 1h;

methyl iodide; In tetrahydrofuran; mineral oil; for 5h;

Reference yield:

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 1316757-08-0
diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 1.5 h / -78 °C

1.2: 0.17 h

2.1: L-Selectride / tetrahydrofuran / 18 h / -78 - 20 °C

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

4.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C

4.2: 36 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h

7.2: 5 h

With copper(I) bromide dimethylsulfide complex; L-Selectride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; mineral oil;

Reference yield:

: 1316756-60-1
(1S,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl methanesulfonate

: 1316757-08-0
diethyl {(1R,3S,4R)-4-[bis(3-methylbutyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}(methyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C

1.2: 36 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h

4.2: 5 h

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; mineral oil;