Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester

Base Information

• Chemical Name: Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester
• CAS No.: 161639-07-2
• Molecular Formula: C₁₈H₂₇NO₆S
• Molecular Weight: 385.481

Synonyms:Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester

Chemical Property of Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester

Chemical Property:

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Technology Process of Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester

There total 6 articles about Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

[3-Iodomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester (161639-05-0) + tiolacetic acid (507-09-5) → Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester (161639-07-2)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1016/0040-4039(94)88510-9

Reference yield:

[2-(2-Methoxy-ethoxymethoxy)-5-nitro-phenyl]-methanol (161009-58-1) → Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester (161639-07-2)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol

3: NEt₃ / tetrahydrofuran / 25 °C

4: NaI / acetone

5: 79 percent / NEt₃ / tetrahydrofuran

With hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/0040-4039(94)88510-9

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Thioacetic acid S-[5-tert-butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyl] ester (161639-07-2)

Guidance literature:

Multi-step reaction with 4 steps

2: NEt₃ / tetrahydrofuran / 25 °C

3: NaI / acetone

4: 79 percent / NEt₃ / tetrahydrofuran

With triethylamine; sodium iodide; In tetrahydrofuran; acetone;

DOI:10.1016/0040-4039(94)88510-9

upstream raw materials:

[3-Iodomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

tiolacetic acid

di-tert-butyl dicarbonate

[3-Hydroxymethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

Downstream raw materials:

C₃₂H₄₈N₂O₁₀S₂

[4-(2-Methoxy-ethoxymethoxy)-3-(pyridin-2-yldisulfanylmethyl)-phenyl]-carbamic acid tert-butyl ester

(R)-3-[5-tert-Butoxycarbonylamino-2-(2-methoxy-ethoxymethoxy)-benzyldisulfanyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid methyl ester

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