2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

Base Information

Chemical Name:2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide
CAS No.:359879-83-7
Molecular Formula:C₂₃H₂₄ClF₃N₂O₂
Molecular Weight:452.904
Hs Code.:

Synonyms:2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

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Chemical Property of 2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

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Technology Process of 2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

There total 3 articles about 2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 359878-15-2
4-(4-methylbenzylamino)-1-(trifluoroacetyl)piperidine

: 25026-34-0
4-chlorophenacetyl chloride

: 359879-83-7
2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

Guidance literature:: 4-(4-methylbenzylamino)-1-(trifluoroacetyl)piperidine; With triethylamine; In dichloromethane; for 0.166667h; Cooling with ice;

4-chlorophenacetyl chloride; In dichloromethane; for 1.25h; Cooling with ice;

Reference yield:

: 65220-86-2
1-(trifluoroacetyl)-4-piperidone

: 359879-83-7
2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium cyanoborohydride / methanol / 20 h / pH 5

2.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

2.2: 1.25 h / Cooling with ice

With sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dichloromethane;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 359879-83-7
2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / Cooling with ice

2.1: acetic acid; sodium cyanoborohydride / methanol / 20 h / pH 5

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 1.25 h / Cooling with ice

With sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dichloromethane;