(E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

Base Information

Chemical Name:(E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate
CAS No.:1365555-22-1
Molecular Formula:C₂₇H₂₈BrNO₄S
Molecular Weight:542.494
Hs Code.:

Synonyms:(E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

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Chemical Property of (E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

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Technology Process of (E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

There total 5 articles about (E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₀BrNO₃S

: 3282-30-2
pivaloyl chloride

: 1365555-22-1
(E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja2109097

Reference yield:

: (Z)-N-(4-hydroxybut-2-enyl)-4-methyl-N-(3-phenylprop-2-ynyl)benzenesulfonamide

: 1365555-22-1
(E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.1: tetrahydrofuran / 20 °C / Inert atmosphere

2.2: Saturated solution

3.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; silver nitrate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ja2109097

Reference yield:

: 591-50-4
iodobenzene

: 1365555-22-1
(E)-6-(N-(3-phenylprop-2-ynyl)-N-tosylamino)-1-bromohex-4-en-1-yn-3-yl pivalate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 24 h / 20 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Saturated solution

4.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

5.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; silver nitrate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ja2109097