(S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

Base Information

Chemical Name:(S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester
CAS No.:143918-05-2
Molecular Formula:C₁₅H₁₆Cl₃NO₇
Molecular Weight:428.654
Hs Code.:

Synonyms:(S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

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Chemical Property of (S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

Chemical Property:

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Technology Process of (S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

There total 1 articles about (S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3940-66-7
L-Asparaginsaeure-4-(4-methoxy-benzylester)

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 143918-05-2
(S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

Guidance literature:: With sodium hydroxide; sodium hydrogencarbonate; Multistep reaction; 2.) dioxane;
DOI:10.1021/ja9740071

Reference yield: 73.0%

: 88224-03-7
L-leucine allyl ester hydro-p-toluenesulfonate

: 143918-05-2
(S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

: 186504-26-7
(S)-2-[(S)-3-(4-Methoxy-benzyloxycarbonyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionylamino]-4-methyl-pentanoic acid allyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja9740071

Reference yield:

: 143918-05-2
(S)-2-(2,2,2-Trichloro-ethoxycarbonylamino)-succinic acid 4-(4-methoxy-benzyl) ester

: 204993-00-0
(S)-N-[(S)-1-((S)-1-Allyloxycarbonyl-2-benzyloxy-ethylcarbamoyl)-3-methyl-butyl]-3-(2,2,2-trichloro-ethoxycarbonylamino)-succinamic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / EDACI, NMM, HOBt / dimethylformamide; CH₂Cl₂

2: Pd(PPh₃)4, morpholine / tetrahydrofuran

3: IIDQ / CH₂Cl₂

With morpholine; 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja9740071