(S)-2-amino-3-phenyl-N-propylpropanamide

Base Information

• Chemical Name: (S)-2-amino-3-phenyl-N-propylpropanamide
• CAS No.: 35373-94-5
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.288
• Mol file: 35373-94-5.mol

Synonyms:(S)-2-amino-3-phenyl-N-propylpropanamide

Chemical Property of (S)-2-amino-3-phenyl-N-propylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-3-phenyl-N-propylpropanamide

There total 7 articles about (S)-2-amino-3-phenyl-N-propylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ZPheNHPr (214475-40-8) → (S)-2-amino-3-phenyl-N-propylpropanamide (35373-94-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; Inert atmosphere;

DOI:10.1039/c4ob02003k

Reference yield:

N-Cbz-L-Phe (1161-13-3) → (S)-2-amino-3-phenyl-N-propylpropanamide (35373-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC

2: H₂

With hydrogen; dicyclohexyl-carbodiimide;

DOI:10.3987/COM-05-S(T)58

Reference yield:

N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester (3397-32-8) → (S)-2-amino-3-phenyl-N-propylpropanamide (35373-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / Heating

2: HBr; AcOH / 20 °C

With hydrogen bromide; acetic acid; In tetrahydrofuran;

DOI:10.1016/S0040-4039(03)01705-2

upstream raw materials:

propylamine

H-Phe-OEt

ZPheNHPr

L-phenylalanine

Downstream raw materials:

(S)-3-phenyl-N₁-phenylpropane-1,2-diamine

C₂₀H₃₁N₃O₄

C₂₈H₃₇N₃O₆

C₂₉H₃₃N₃O₄