1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE

Base Information

• Chemical Name: 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE
• CAS No.: 289725-89-9
• Molecular Formula: C24H22 N2 O
• Molecular Weight: 354.451
• Mol file: 289725-89-9.mol

Synonyms:1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE

Chemical Property of 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE

Chemical Property:

• Vapor Pressure: 4.88E-11mmHg at 25°C
• Refractive Index: 1.598
• Boiling Point: 536.4°Cat760mmHg
• Flash Point: 278.2°C
• PSA: 27.05000
• Density: 1.09g/cm³
• LogP: 5.77730

Purity/Quality:

1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE

There total 9 articles about 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-ethyl-5-(4-methoxyphenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole → 1,3-diphenyl-4-ethyl-5-(4'-methoxyphenyl)-1H-pyrazole (289725-89-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 110.4h;

DOI:10.1021/ol0062650

Reference yield: 70.0%

C18H18O2S + phenylhydrazine (100-63-0) → 1,3-diphenyl-4-ethyl-5-(4'-methoxyphenyl)-1H-pyrazole (289725-89-9)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 20 ℃; Temperature; Solvent; regioselective reaction; Reflux;

DOI:10.1021/jo400599e

Reference yield: 61.0%

4-ethyl-5-(4'-methoxyphenyl)-3-(methylthio)-1-phenyl-1H-pyrazole (871110-29-1) + phenylmagnesium bromide → 1,3-diphenyl-4-ethyl-5-(4'-methoxyphenyl)-1H-pyrazole (289725-89-9)

Guidance literature:

phenylmagnesium bromide; With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; benzene; for 0.25h; Heating;

4-ethyl-5-(4'-methoxyphenyl)-3-(methylthio)-1-phenyl-1H-pyrazole; In diethyl ether; benzene; for 12h; Heating;

DOI:10.1021/jo051771u

upstream raw materials:

4-ethyl-5-(4'-methoxyphenyl)-3-(methylthio)-1-phenyl-1H-pyrazole

phenylhydrazine

trans-4-methoxychalcone

5-(4-methoxyphenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole