(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

Base Information

Chemical Name:(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate
CAS No.:1622104-31-7
Molecular Formula:C₁₅H₂₅O₅PSi
Molecular Weight:344.42
Hs Code.:

Synonyms:(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

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Chemical Property of (E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

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Technology Process of (E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

There total 1 articles about (E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2372-33-0
chlorodimethyl(4-methoxyphenyl)silane

: 80986-52-3
dimethyl (1-methoxyprop-2-enyl)phosphonate

: 1622104-31-7
(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

: 22868-26-4
(p-methoxyphenyl)dimethylsilanol

Guidance literature:: dimethyl (1-methoxyprop-2-enyl)phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

chlorodimethyl(4-methoxyphenyl)silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;
DOI:10.1002/anie.201400315

Reference yield: 82.0%

: 1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalene-2-carbaldehyde

: 1622104-31-7
(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

: 1622104-32-8
{[1E,3Z]-3-methoxy-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]buta-1,3-dien-1-yl}(4-methoxyphenyl)dimethylsilane

Guidance literature:: (E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -40 ℃; for 0.25h;

1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalene-2-carbaldehyde; In tetrahydrofuran; toluene; at -78 ℃; for 1.25h;
DOI:10.1002/anie.201400315

Reference yield:

: 1622104-31-7
(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

: 1622104-33-9
(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -40 °C

1.2: 1.25 h / -78 °C

2.1: trichloroacetic acid / dichloromethane; water / 0.75 h / 20 °C

3.1: isopropylmagnesium bromide; copper(I) iodide-lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; diethyl ether; 2-methyltetrahydrofuran / 0.5 h / -40 - -20 °C

3.2: 20 °C

With chloro-trimethyl-silane; copper(I) iodide-lithium chloride; isopropylmagnesium bromide; potassium hexamethylsilazane; trichloroacetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1002/anie.201400315