(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

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Chemical Name:(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate
CAS No.:1622104-33-9
Molecular Formula:C₅₁H₇₀O₁₇Si₂
Molecular Weight:1011.28
Hs Code.:

(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

Synonyms:(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

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Chemical Property of (E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

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Technology Process of (E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

There total 5 articles about (E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₂₁H₃₃IO₇Si

: 1622104-39-5
(E)-4-[(4-methoxyphenyl)dimethylsilyl]-1-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]but-3-en-2-one

: 1622104-33-9
(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

Guidance literature:: C₂₁H₃₃IO₇Si; (E)-4-[(4-methoxyphenyl)dimethylsilyl]-1-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]but-3-en-2-one; With chloro-trimethyl-silane; copper(I) iodide-lithium chloride; isopropylmagnesium bromide; In tetrahydrofuran; 2-methyltetrahydrofuran; diethyl ether; at -40 - -20 ℃; for 0.5h;

With sulfuric acid; In tetrahydrofuran; 2-methyltetrahydrofuran; diethyl ether; at 20 ℃;
DOI:10.1002/anie.201400315

Reference yield:

: 1622104-31-7
(E)-dimethyl {1-methoxy-3-[(4-methoxyphenyl)dimethylsilyl]prop-1-en-1-yl}phosphonate

: 1622104-33-9
(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -40 °C

1.2: 1.25 h / -78 °C

2.1: trichloroacetic acid / dichloromethane; water / 0.75 h / 20 °C

3.1: isopropylmagnesium bromide; copper(I) iodide-lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; diethyl ether; 2-methyltetrahydrofuran / 0.5 h / -40 - -20 °C

3.2: 20 °C

With chloro-trimethyl-silane; copper(I) iodide-lithium chloride; isopropylmagnesium bromide; potassium hexamethylsilazane; trichloroacetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1002/anie.201400315

Reference yield:

: 2372-33-0
chlorodimethyl(4-methoxyphenyl)silane

: 1622104-33-9
(E)-methyl 6-[2-(tert-butyldimethylsiloxy)-3-methoxy-3-oxoprop-1-en-1-yl]-2-methoxy-3-(methoxymethoxy)-4-{1-[(4-methoxyphenyl)dimethylsilyl]-3-oxo-4-[1,4,5,6,8-pentamethoxy-3-(methoxymethoxy)naphthalen-2-yl]butyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -40 °C

2.2: 1.25 h / -78 °C

3.1: trichloroacetic acid / dichloromethane; water / 0.75 h / 20 °C

4.1: isopropylmagnesium bromide; copper(I) iodide-lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; diethyl ether; 2-methyltetrahydrofuran / 0.5 h / -40 - -20 °C

4.2: 20 °C

With n-butyllithium; chloro-trimethyl-silane; copper(I) iodide-lithium chloride; isopropylmagnesium bromide; potassium hexamethylsilazane; trichloroacetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene;
DOI:10.1002/anie.201400315