2-Amino-4-chloro-5-methylbenzonitrile

Base Information

Chemical Name:2-Amino-4-chloro-5-methylbenzonitrile
CAS No.:289686-80-2
Molecular Formula:C8H7 Cl N2
Molecular Weight:166.61
Hs Code.:2926909090
DSSTox Substance ID:DTXSID50445987
Wikidata:Q82264542
Mol file:289686-80-2.mol

Synonyms:289686-80-2;2-AMINO-4-CHLORO-5-METHYLBENZONITRILE;2-amino-4-chloro-5-methyl-benzonitrile;2-Cyano-5-chloro-4-methylaniline;SCHEMBL404910;DTXSID50445987;UUWBRWXXBHDPMM-UHFFFAOYSA-N;5-chloro-2-cyano-4-methylaniline;AB3018;MFCD08437620;AKOS006290621;SB36404;AS-44674;CS-0340521;FT-0691538;2-Amino-4-chloro-5-methyl-benzonitrile, AldrichCPR;F8885-5349

Suppliers and Price of 2-Amino-4-chloro-5-methylbenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-4-chloro-5-methylbenzonitrile
50mg
$ 110.00

J&W Pharmlab
2-Amino-4-chloro-5-methyl-benzonitrile 97%
50mg
$ 117.00

J&W Pharmlab
2-Amino-4-chloro-5-methyl-benzonitrile 97%
1g
$ 380.00

Chemcia Scientific
2-Amino-4-chloro-5-methyl-benzonitrile 95%
1 G
$ 350.00

American Custom Chemicals Corporation
2-AMINO-4-CHLORO-5-METHYL BENZONITRILE 95.00%
5MG
$ 495.56

Alichem
2-Amino-4-chloro-5-methylbenzonitrile
1g
$ 277.95

AK Scientific
2-Amino-4-chloro-5-methylbenzonitrile
250mg
$ 293.00

AccelPharmtech
2-amino-4-chloro-5-methylbenzonitrile 97.00%
25G
$ 6000.00

AccelPharmtech
2-amino-4-chloro-5-methylbenzonitrile 97.00%
5G
$ 3230.00

AccelPharmtech
2-amino-4-chloro-5-methylbenzonitrile 97.00%
1G
$ 1890.00

Total 9 raw suppliers

Chemical Property of 2-Amino-4-chloro-5-methylbenzonitrile

Chemical Property:

PSA：49.81000
LogP:2.68348
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:166.0297759
Heavy Atom Count:11
Complexity:184

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-chloro-5-methylbenzonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1Cl)N)C#N

Technology Process of 2-Amino-4-chloro-5-methylbenzonitrile

There total 5 articles about 2-Amino-4-chloro-5-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102170-52-5
2-bromo-5-chloro-4-methylaniline

: copper(l) cyanide

: 289686-80-2
2-cyano-5-chloro-4-methylaniline

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 163 ℃; for 2h;

Reference yield:

: 95-74-9,827571-80-2
3-chloro-p-toluidine

: 289686-80-2
2-cyano-5-chloro-4-methylaniline

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine / ethyl acetate / 18 h / 20 °C

2: 48 percent / glacial AcOH; Br₂ / 1.5 h / 15 °C

3: 94 percent / AcOH; conc. HCl / 24 h / 118 °C

4: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C

With pyridine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; bromine; acetic acid; In ethyl acetate;
DOI:10.1021/jm011081s