Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

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Chemical Name:Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate
CAS No.:1290118-45-4
Molecular Formula:C₄₀H₆₆N₄O₁₂
Molecular Weight:794.984
Hs Code.:

Synonyms:Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

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Chemical Property of Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

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Technology Process of Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

There total 7 articles about Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1290118-44-3
ethyl (4E)-2-N,N-bis[2-[N',N'-bis[(ethoxycarbonyl)methyl]amino]ethyl]amino-5-(4-[2-[(t-butoxy)carbonylamino]ethyl]phenyl)pento-4-enolate

: 1290118-45-4
Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 11h;

Reference yield: 97.0%

: 1309680-31-6
C₄₀H₆₄N₄O₁₂

: 1290118-45-4
Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

Guidance literature:: With palladium on carbon; hydrogen; In ethanol; at 20 ℃; for 11h;
DOI:10.1055/s-0030-1259545

Reference yield:

: 51992-77-9
pentaethyl diethylenetriamine-N,N,N',N'',N''-pentaacetate

: 1290118-45-4
Ethyl 2-[N,N-bis(2-{N',N'-bis[(ethoxycarbonyl)methyl]amino}ethyl)amino]-5-(4-{2-[(t-butoxy)carbonylamino]ethyl}phenyl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 39 h / 40 °C

1.2: 70 h / 80 °C

2.1: palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / water; acetonitrile / 8 h / 60 °C

3.1: palladium on carbon; hydrogen / ethanol / 11 h / 20 °C

With palladium on carbon; hydrogen; palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; 1.1: Stevens rearrangement / 1.2: Stevens rearrangement / 2.1: Mizoroki-Heck reaction;
DOI:10.1055/s-0030-1259545