{4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

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Chemical Name:{4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid
CAS No.:1245940-68-4
Molecular Formula:C₁₉H₂₅ClF₃N₃O₄Si
Molecular Weight:479.959
Hs Code.:

Synonyms:{4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

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Chemical Property of {4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

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Technology Process of {4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

There total 8 articles about {4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 959140-61-5
{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1245940-68-4
{4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Guidance literature:: {3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid; tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

for 0.5h;

pH=4;

Reference yield:

: 1228650-23-4
5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-oxopropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1245940-68-4
{4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 1.5 h / Cooling with ice

2.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

3.1: ethyl acetate; 2-Methylpentane / Resolution of racemate

4.1: lithium hydroxide / water; methanol / 1 h / 20 °C

4.2: pH 1 - 2

5.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5.2: 0.5 h

5.3: pH 4

With 1H-imidazole; sodium tetrahydroborate; potassium carbonate; potassium iodide; lithium hydroxide; In methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1245940-68-4
{4-[(2S)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 20 - 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate / methanol / 1.5 h / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: ethyl acetate; 2-Methylpentane / Resolution of racemate

7.1: lithium hydroxide / water; methanol / 1 h / 20 °C

7.2: pH 1 - 2

8.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

8.2: 0.5 h

8.3: pH 4

With 1H-imidazole; sodium tetrahydroborate; water; potassium carbonate; potassium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; pyridine; methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;